Molecular Diagnostic System

Source MDx's integrated molecular diagnostic system consists of three core elements:

• Precision Profiles™, quantitative polymerase chain reaction (QPCR) assays that measure gene expression profiles in pre-clinical and clinical settings
• Normal Reference Ranges that target specific gene expression ranges established from normal healthy individuals or clinically relevant clinical subpopulations enabling comparisons to normal and treat-to-normal strategies
• Sophisticated, proprietary statistical methodologies establishing multi-gene models

Source MDx is the first molecular diagnostics company to discover, reduce to practice and patent an RNA transcript-based molecular diagnostic system measuring cellular gene expression in whole blood. Source MDx's system can track an individual's current health, disease status and response to drug therapy. With nearly a decade of experience using its system in more than 150 pre-clinical projects and clinical trials with academic institutions and pharmaceutical companies, the company has developed methods for measuring gene expression in ways that are significantly more consistent and reproducible across gene panels of than previously known or thought possible.

Source MDx has:

• Established that these methods reveal biological phenomena that were previously difficult or impossible to observe using traditional gene expression measurement techniques.
• Established that gene expression levels must exist within tolerable limits in order for an individual to maintain normal health.
• Demonstrated that rigorous characterization of the range of normal levels of gene expression are necessary for the characterization of abnormal molecular patterns that define a variety of disease states.
• Shown that gene expression in whole blood is extremely consistent over time in normal, healthy individuals.
• Shown that such consistency also exists within a population of normal healthy donors.